Abstract

NINA G., Nelson M.  and  SARDINAS C., Susan. Induction outcomes in children with acute lymphoblastic leukemia in the hospital del niño "Ovidio Aliaga Uria", period 2013-2015: case series. Cuad. - Hosp. Clín. [online]. 2018, vol.59, n.2, pp.17-26. ISSN 1562-6776.

Abstract INTRODUCTION: Acute lymphoblastic leukemia is the most common neoplasm in pediatrics. To date, the clinical aspects and results of the treatment of this disorder in Bolivia have not been studied. OBJECTIVE: To describe the results of induction to remission in a group of children with acute lymphoblastic leukemia. METHODS: Descriptive, cross-sectional and analytical study of a case series treated at Hospital del Niño "Ovidio Aliaga Uría" during the period 2013-2015. RESULTS: Twenty-five cases, with an average age of 5.8 years, were included in the analysis, 60% of which were female. The common clinical manifestations at the diagnosis were pallor, fever and anorexia with 68%, 64% and 60% respectively. 100% of the cases corresponded to phenotype B, with 96% for common B subtype. At the end of the induction with the institutional protocol (Total Therapy XV modified), 92% achieved complete remission, the mortality during induction was 4%. The most frequent complication during induction was haematological toxicity, followed by infectious morbidity. 92% required transfusion support during treatment. The OS and EFS estimated at 2 years was 95% and 56%, respectively. CONCLUSION: Therapeutic response to induction of remission with the institutional protocol is comparable to previous studies. SLE is lower than previously reported data, with treatment abandonment being a key factor associated with this finding.

Keywords : Acute lymphoblastic leukemia; treatment; Bolivia; developing country.

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