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Revista Médica La Paz
On-line version ISSN 1726-8958
Abstract
TORREZ SANTOS, Eynar Rodrigo and VALLEJOS MITA, Gloria Martha. SAFETY COMPARISON BETWEEN PROPOFOL-FENTANYL VS PROPOFOL-KETAMINE SEDOANALGESIA IN PATIENTS WITH COVID-19 WHO UNDERWENT COLONOSCOPIES. Rev. Méd. La Paz [online]. 2023, vol.29, n.1, pp.44-51. Epub June 30, 2023. ISSN 1726-8958.
Introduction:
Anesthetic procedures outside the operating room have increased. Now the challenge of managing patients with COVID-19 is included, within these is the colonoscopy that must be performed under sedo-analgesia, there is no an ideal drug so combinations are made for the safety of the patient and the health staff.
Objective:
To compare the safety of sedo-analgesia with propofol-fentanyl vs propofol-ketamine in patients with COVID-19 undergoing colonoscopy.
Material and methods:
An experimental, cross-sectional, comparative study was carried out in 60 patients submitted to colonoscopy, these were selected by succession into 2 groups: group A (propofol-fentanyl) and group B (propofol- ketamine). Group A: fentanyl 1 ug/kg and later propofol at 0.5 to 1.5 mg/kg, and maintenance with propofol boluses at 0.5 mg/kg. Group B: a mixture of propofol- ketamine was prepared at a ratio of 4:1, in induction propofol (1 mg/kg) and ketamine (0.25 mg/kg) were used, propofol maintenance (5 mg/kg/h) and ketamine (1.25 mg/ kg/h). The information was collected from primary sources, the statistical program SPSS version 22.0 was used.
Results:
Group A had a tendency to bradycardia and hypotension, as well as greater respiratory depression with a frequency of 4 (13.3%) in relation to 1 (3.3%) in the ketofol group.
Conclusion:
Ketofol has shown to be safer compared to propofol-fentanyl for colonoscopy sedo-analgesia in COVID-19 patients.
Keywords : sedo-analgesia; ketofol; fentanyl; ketamine; COVID-19; colonoscopy.