Abstract

ARANCIBIA V., Oliver; BUSTAMANTE M., Dayana; OMONTE G., Silvana  and  SANTA CRUZ, Adriana. Relation of the herpes simplex virus with the alzheimer's disease. Rev Cient Cienc Méd [online]. 2012, vol.15, n.2, pp.41-44. ISSN 1817-7433.

Alzheimer's disease has been investigated for many years and its causes are unknown. According to research recognized simplex type 1 virus, which acts in combination with the ApoE-₃4 genetic factor, as a risk factor that increases the susceptibility of the disease.There are several possible ways in which HSV1 (herpes simplex virus type 1) could lead to Alzheimer's disease, such as regulation by different enzymes and in particular specific kinases, their effect on cell cycle, autophagy, and their oxidative, inflammatory effects and related neuroglobin. Currently there developing possible experimental treatments in animals, in order to fortify the immune system against herpes simplex virus type 1, to simultaneously become a form of disease prevention. It was also proved that some antiviral medication, reduce she formation of senile plaques. In conclusion, herpes-Alzheimer relationship requires many factors to their development, many of them are genetic factors or defective proteins and enzymes.

Keywords : Alzheimer diseasse; Herpes simplex virus; apolipo protein E; Amiloid plaque.

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