Abstract

GUERRERO, Karen Jhuliana Robles  and  BERNITA, Rosa Elizabeth Solorzano. Neurobiology of major depressive disorder. Vive Rev. Salud [online]. 2022, vol.5, n.15, pp.819-827.  Epub Dec 21, 2022. ISSN 2664-3243.  https://doi.org/10.33996/revistavive.v5i15.190.

Depression is currently one of the most frequently addressed pathologies, the presence of characteristic symptoms causes great caution and requires high personal care, in addition, the suffering of this disease is directly linked to the neurobiological aspects that explain the processes within the central nervous system. Objective. The aim of the present study is to describe the following theories of the neurology of major depression: monoamine theory, neurotrophic theory and inflammatory theory together with their relation to depression. Methodology. A bibliographic review of the scientific literature related to the neurobiology of major depression was carried out, including experimental studies, original studies, meta-analysis and official pages. The PubMed database was used, and Google scholar, whose documents were published between 2015 to 2022 in Spanish and English language; the terms MESH and DeCs were used: "depression" "inflammation" "neurobiology" "biogenic monoamines". Conclusion: It is concluded that, despite new discoveries regarding different mechanisms of the neurobiology of depression, there are still undiscovered gaps that prevent the development of a unified theory of etiology.

Keywords : Depression; Inflammation; Neurobiology; Biogenic Monoamines.

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