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Gaceta Médica Boliviana
Print version ISSN 1012-2966On-line version ISSN 2227-3662
Abstract
VELARDE-NEGRETE, Jans et al. Analgesic and gastroprotective activity of extracts and infusion of Minthostachys Mollis and Plantago Major. Gac Med Bol [online]. 2022, vol.45, n.2, pp.160-166. Epub Dec 01, 2022. ISSN 1012-2966. https://doi.org/10.47993/gmb.v45i2.441.
Muña and llantén are plants from the Andean region of Bolivia, traditionally their leaves are used as an infusion due to their analgesic and gastroprotective properties.
Objective:
to evaluate the analgesic and gastroprotective activity of extracts and infusion of muña (Minthostachys mollis) and llantén (Plantago major) leaves, using biological tests in Rattus norvegicus.
Methods:
an experimental, prospective, longitudinal study was conducted in which the analgesic and gastroprotective activity was evaluated in 30 Rattus norvegicus divided into six lots: control, standard, problem I, II, III, IV, to which abdominal convulsions were induced with glacial acetic acid and gastric ulcers with absolute ethanol.
Results:
the infusion of muña and llantén presented 81.4% analgesic activity and an effectiveness percentage above 100%, 60% gastroprotective activity and 100% effectiveness in relation to the number of lesions. Similarly, 69.6% gastroprotective activity and 95.9% effectiveness with respect to the degree of injury. These percentages described were higher in comparison to the percentages of muña extract, llantén extract, combined extracts. The ANOVA one-factor Kruskal-Wallis test revealed a statistically significant difference (p<0.05 (p=0.013 number of convulsions); 95% CI) in analgesic activity and a non-significant difference in gastroprotective activity (p>0.05 (p=0.167 number of lesions and p=0.384 degree of injury); 95% CI).
Conclusions:
the infusion of muña and llantén has better analgesic and gastroprotective activity compared to the extracts.
Keywords : analgesics; plantago major; stomach ulcer; tannins.