Abstract

TORREZ, Deyni; CURCUY, Milet  and  CARVAJAL, Roger. Autoantibodies Profiles in arthropaties. Cuad. - Hosp. Clín. [online]. 2014, vol.55, n.4, pp.24-35. ISSN 1562-6776.

Between the Autoimmune Diseases, Rheumatoid Arthritis (RA) is one of the most studied, due to its high prevalence. Several studies have reported as possible shooting mechanism the existence of an immune response against Collagen type II. The present work look for contributing to the knowledge and meaning of the autoimmune process through determinations of different serum antibodies in subjects with Rheumatoid Arthritis (diagnosed under the American College of Rheumatology criteria) and in subjects with unspecific arthralgia in comparison with normal subjects. For this purpose, a transversal descriptive study was carried out, determining the presence of anti-collagen type II antibodies, anti-CCP (Citrulinated Cyclic Peptides) antibodies and anti-synovial antibodies by indirect immunofluorescence (IFI) in sera, usingpreviouslystandardizedmethods according to conventional procedures. No significant differences was found between the averages of the levels of anti-collagen type II in the 3 groups; however, the distribution of the antibody titles shows, in the three groups, curves of frequency of a bi-modal type, with profiles totally different between them. In this order, inside the group with Rheumatoid Arthritis it was identified a subgroup formed by the 20% of the subjects that presents very high levels of anti-collagen type II Antibodies (over the two standard deviations), made byyoung adults (average age 41 years) that did not receive inmunosuppresive treatment. It was not found relationship between the levels of anti-collagen type II antibodies, anti-CCP antibodies and anti-synovial antibodies. The significance of these findings is discussed.

Keywords : Anti-collagen type II antibody; anti-cyclic citrullinated peptides antibody; anti-synovial antibody; Rheumatoid Arthritis.