Abstract

CENTURION, Juan R.; GALEANO, Antonia K; KENNEDY, María L.  and  CAMPUZANO-BUBLITZ, Miguel A.. Murine models used in research on Diabetes mellitus. Rev.Cs.Farm. y Bioq [online]. 2022, vol.10, n.2, pp.53-68. ISSN 2310-0265.  https://doi.org/10.53287/eeeh2318fn45v.

Diabetes mellitus occurs when the pancreas produces an insufficient amount of insulin or the body does not use this hormone correctly. Generally, due to the pathogenesis, it is classified into two types: type 1 diabetes mellitus (insulin dependent) and type 2 diabetes mellitus. In recent years, it has become one of the main causes of death worldwide and a risk factor for the development of various pathologies. Due to the implication in human health and its increasing distribution worldwide, it has become one of the research topics of several groups, who are seeking to better understand diabetes pathogenesis and develop possible treatments both at the molecular and cellular level. The current research techniques developed include animal models in which this pathology is chemically induced, strains of mice that develop it spontaneously after selective crossing, and those created by the newest genetic engineering techniques. Despite all the effort, there is no single model that presents us with the full range of possibilities that occur in human beings. That is why various models with different characteristics are presented, each one will help us understand this disease a little more.

Keywords : murine models; drug induction; autoimmune models; spontaneous models.

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