Objective.

To determine the antimicrobial resistance in E. coli isolated from urine cultures, during January - July 2019, in patients who attended the Neolab clinical laboratory.

Materials and Methods.

The research is quantitative, documentary, descriptive longitudinal cut. It was developed in the city of Cuenca, with a universe of 936 patients treated in the Neolab clinical laboratory from January to July 2019 with a non-probabilistic convenience sampling with which a sample of 330 data records was obtained, whose urine cultures presented E coli.

Results.

Resistance of 55.15% was observed in Amoxicillin, Nalidixic Acid 50.91% and Trimethoprim Sulfamethoxazole 46.67%, Ciprofloxacin 26.67%, greater resistance is evidenced in women both in β-lactams, Quinolones, Sulfas and Macrolides It was found that the largest number of patients are within the group of adults that represents 54.4% and the elderly with 25.3%.

Conclusions.

The high resistance to the studied antibiotics could suggest an empirical use of them, the detection of these figures represents an alarm signal. Self-medication facilitated by the over-the-counter sale of antimicrobials worsens the problem, requiring strict control and timely legislation.