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Vive Revista de Salud
versão impressa ISSN 2664-3243
Resumo
ENCALADA ALVAREZ, Rosa Carolina e ARTEAGA SARMIENTO, Sandra Denisse. Epidemiological surveillance of multidrug-resistant Acinetobacter baumannii at hospital level. Vive Rev. Salud [online]. 2021, vol.4, n.12, pp.66-86. ISSN 2664-3243. https://doi.org/10.33996/revistavive.v4i12.109.
Acinetobacter baumannii is considered as a bacterium of great clinical importance due to the resistance it has acquired to antimicrobials, which has triggered complications when referring an antibiotic therapy, prolonging the stay in the hospital of patients infected with this bacterium, causing a high degree of mortality due to its high proliferation capacity between different hospital areas.
Objective.
To describe the most relevant aspects about the epidemiology of the outbreaks caused by Acinetobacter baumannii in Latin America, as well as the different resistance mechanisms that this pathogen has acquired thus causing inconveniences when using the different therapeutic treatments.
Materials and methods.
a systematic review was carried out, under the PRISMA declaration, for the search of the information were used databases such as: Scielo, Redalyc, Google academic, 43 articles were found of which only 25 were valid for research.
Results.
The resistance of Acitetobacter baumannii to different antibiotic groups has increased over the years. This increase in resistance is due to several factors among which stand out: β-lactamases directed against beta-lactams, either broad spectrum or carbapenemases; variations in proteins of the outer membrane, ejection pumps, loss of porins, modifications of the place (target) of action of the antibiotics and alterations in the expression of penicillin-fixing proteins. This ability depends in part on the ability of this bacterium to acquire resistance genes, often through horizontal gene transfer.
Conclusions.
A. baumannii has developed multiple antibiotic resistance mechanisms, which increase the harmful consequences of this potential pathogen and represents a major challenge for patients and health personnel.
Palavras-chave : Acinetobacter infections; Acinetobacter baumannii; hospital infection; Epidemiological surveillance; Bacterial resistance.