Resumo

ITURRI, Jaime P  e  RODRIGO, Gloria DC. Damsin, coronopilin and santamarin, esquiterpenelactones that manifest a cytotoxic activity, DNA damage capability and apoptosis capability on cancer cells lines a549, HeLa and Panc-1. Rev. Bol. Quim [online]. 2018, vol.35, n.1, pp.06-14. ISSN 0250-5460.

Cancer represents a group of diseases characterized by abnormal cell proliferation, currently represents major health problem. It is in this sense that derivatives of natural products are an important source of investigation as possible treatments. In the present research antiproliferative capacity, DNA damage and apoptotic effects of three sesquiterpene lactones (damsin, coronopilin and santamarin) were assayed in the following cancer cell lines: A549 (non-small cell lung cancer), HeLa (cervical cancer) and Panc-1 (pancreatic cancer). In A549 cell line all molecules showed antiproliferative effect at every concentration without presenting DNA damage, santamarin and coronopilin increased the amount of apoptotic cells at high concentrations. Damsin and santamarin showed antiproliferative effect on HeLa cells at all concentration but coronopilin only at high, similarly DNA damage and apoptotic effect was observed for coronopilin and santamarin. For Panc-1 cell line, damsin and santamarin showed antiproliferative effect, DNA damage was observed at high concentrations of the three molecules, without effect on apoptosis induction.

Palavras-chave : Sesquiterpene-lactones; Cancer; Damsin; Coronopilin; Santamarin; DNA damage; Apoptosis.

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